PrEP vs. PEP: Understanding the Difference and When to Use Each

Advancements in HIV prevention have provided effective tools for reducing the risk of HIV transmission. Among these methods, PrEP (Pre-Exposure Prophylaxis) and PEP (Post-Exposure Prophylaxis) are two critical options. Both are highly effective, but they serve different purposes. 

In this blog, Novus—a leading sexual health organization in Pennsylvania—explores the differences between PrEP and PEP, helping you understand when and how to use each.

What is PrEP?

PrEP, short for Pre-Exposure Prophylaxis, is a medication taken daily by individuals who are HIV-negative to prevent infection. It is most effective when taken consistently and is recommended for people at higher risk of HIV, such as:

• Those with an HIV-positive partner.
• People who engage in sexual activity without consistent condom use.
• Individuals who inject drugs and share needles.

PrEP reduces the risk of HIV transmission through sexual contact by approximately 99% when taken as prescribed. For people who inject drugs, it reduces the risk by at least 74%.

What is PEP?

PEP, or Post-Exposure Prophylaxis, is a medication taken after potential exposure to HIV. It must be started within 72 hours of exposure to be effective and is intended for emergency situations, such as:

• Unprotected sexual contact with someone who might have HIV.
• Needle-sharing or accidental needle-stick injuries.
• Sexual assault.

PEP is taken daily for 28 days and works by preventing the virus from establishing itself in the body.

Key Differences Between PrEP and PEP

1. Timing: PrEP is proactive and taken daily before exposure; PEP is reactive and taken after potential exposure.
2. Purpose: PrEP is for ongoing prevention, while PEP is for emergency use.
3. Usage Period: PrEP requires consistent, long-term use, whereas PEP is a short-term treatment lasting 28 days.

Should I Choose PrEP or PEP?

• Choose PrEP if you are at a higher, consistent risk of HIV exposure and want a preventive solution.
• Choose PEP if you’ve had a one-time potential exposure to HIV and need an immediate response.

Take Control of Your Sexual Health with PrEP and PEP at Novus

With six locations across Pennsylvania, Novus is here to support your sexual health journey. Whether you’re exploring PrEP for ongoing prevention or need immediate access to PEP, our knowledgeable and affirming team is ready to help.

Take the first step toward a healthier future—contact Novus today and let us guide you in making informed decisions for your well-being.